Research Library
We chose these ingredients because the data is clear. Here are the peer-reviewed studies that informed our formula — with links to the originals.
Showing 15 of 15 studies
Brum JM et al.
Psyllium fiber significantly increased fullness, reduced hunger, and decreased the desire to eat when consumed before meals.
Study Design
Randomized, double-blind, placebo-controlled crossover
Subjects
Healthy adult volunteers
Anderson JW et al.
Daily psyllium intake reduced LDL cholesterol by 7% as an adjunct to a low-fat diet across 8 controlled trials.
Study Design
Meta-analysis of 8 RCTs
Subjects
656 adults with mild-to-moderate hypercholesterolemia
Anderson JW et al.
Post-lunch glucose was 19.2% lower with 5.1g psyllium twice daily. All-day postprandial glucose was 11% lower vs. placebo.
Study Design
Randomized crossover trial
Subjects
34 men with type 2 diabetes and hypercholesterolemia
Pastors JG et al.
Psyllium fiber significantly reduced the rise in post-meal glucose and insulin concentrations in diabetic patients.
Study Design
Clinical trial
Subjects
Patients with non-insulin-dependent diabetes
Noronha JC et al.
5–10g of allulose significantly reduces blood glucose AUC by ~14% after meals and stimulates GLP-1 release from intestinal L-cells.
Study Design
Systematic review and meta-analysis of 8 RCTs
Subjects
Healthy and diabetic adults
Pedret A et al.
Both live and heat-killed BPL1 significantly reduced BMI, waist circumference, and visceral fat area. Associated with increased Akkermansia muciniphila abundance.
Study Design
Randomized, parallel, double-blind, placebo-controlled
Subjects
135 abdominally obese adults over 12 weeks
Companys J et al.
Heat-inactivated BPL1 delivered via enriched food improved cardiometabolic risk factors and positively shifted gut microbiota composition, confirming postbiotic efficacy.
Study Design
Randomized controlled trial
Subjects
Abdominally obese adults
Balaguer F et al.
Lipoteichoic acid from BPL1 directly reduces fat deposition by modulating the IGF-1 signaling pathway — even dead cell components actively prevent fat accumulation.
Study Design
Mechanistic study
Subjects
Cell and organism models
Anton SD et al.
1,000 mcg chromium picolinate reduced food intake by 25%, hunger by 24%, and cravings for high-fat foods — without compensatory hunger despite a 365 cal/day deficit.
Study Design
Randomized, double-blind, placebo-controlled
Subjects
42 overweight women over 8 weeks
Docherty JP et al.
600 mcg chromium picolinate significantly reduced carbohydrate cravings, appetite, and binge eating in adults with high carb cravings, suggesting action on central appetite pathways.
Study Design
Double-blind, placebo-controlled
Subjects
113 adults with atypical depression over 8 weeks
Suksomboon N et al.
Chromium supplementation significantly reduces fasting blood glucose and HbA1c (a long-term blood sugar marker), supporting its role in metabolic optimization.
Study Design
Systematic review and meta-analysis of 22 RCTs
Subjects
Adults across 22 randomized controlled trials
Matsumoto N et al.
Acacia fiber (gum arabic) modulates TGF-beta1 generation through butyrate production, supporting gut barrier integrity and anti-inflammatory signaling.
Study Design
Experimental study
Subjects
In vitro and in vivo models
Spencer SP et al.
Fiber supplementation significantly increased populations of beneficial gut bacteria and boosted production of compounds supporting gut health, mood, and immune function.
Study Design
Longitudinal study
Subjects
120 participants over 6 months
Reynolds A et al.
Higher dietary fiber intake is consistently associated with lower risks of mortality, cardiovascular disease, type 2 diabetes, and colorectal cancer.
Study Design
Systematic reviews and meta-analyses
Subjects
Large-scale population data
Research team
Gel-forming fiber supplementation may interfere with reabsorption of PFAS chemicals bound to bile acids, facilitating their excretion and reducing body burden.
Study Design
Pilot intervention study
Subjects
Animal model (fiber-PFAS binding)